Cynomolgus CD117 / c-kit Protein, His Tag (MALS verified), Unconjugated, Human
Biozol Catalog Number:
ABS-CD7-C52H9-100UG
Supplier Catalog Number:
CD7-C52H9-100ug
Alternative Catalog Number:
ABS-CD7-C52H9-100UG
Manufacturer:
AcroBiosystems
Host:
Human
Category:
Proteine/Peptide
Species Reactivity:
Monkey
Conjugation:
Unconjugated
Mast/stem cell growth factor receptor Kit (cKit), a member of the protein kinase superfamily, Tyr protein kinase family and CSF1/PDGF receptor subfamily, is also known as piebald trait protein (PBT), p145 ckit, tyrosineprotein kinase Kit and CD117,which contains five Iglike C2type (immunoglobulinlike) domains and one protein kinase domain. CD117 acts as cellsurface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, CD117 can activate several signaling pathways. Furthermore, Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. - Proteine/Peptide
