Human CD117 / c-kit Protein, Fc Tag (MALS verified), Unconjugated

Product Overview

• Article Name: Human CD117 / c-kit Protein, Fc Tag (MALS verified), Unconjugated
• Biozol Catalog Number: ABS-CD7-H525B-1MG
• Supplier Catalog Number: CD7-H525b-1mg
• Alternative Catalog Number: ABS-CD7-H525B-1MG
• Manufacturer: AcroBiosystems
• Host: Human
• Category: Proteine/Peptide
• Species Reactivity: Human
• Conjugation: Unconjugated

Product Description

cKIT activation has been shown to have oncogenic activity in gastrointestinal stromal tumors (GISTs), melanomas, lung cancer, and other tumor types. The targeted therapeutics nilotinib and sunitinib have shown efficacy in treating KIT overactive patients, and are in latestage trials in melanoma and GIST. KIT overactivity can be the result of many genomic events from genomic amplification to overexpression to missense mutations. Missense mutations have been shown to be key players in mediating clinical response and acquired resistance in patients being treated with these targeted therapeutics. - Proteine/Peptide

Product Properties

• Molecular Weight: 50.2 kDa
• Tag: C-Fc
• NCBI: 10721
• Buffer: PBS, pH7.4
• Purity: 95%
• Form: Powder
• Target: CD117

Images

Human CD117 Protein, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.