Mouse CD117 / c-kit Protein, Fc Tag (MALS verified), Unconjugated, Human

Product Overview

• Article Name: Mouse CD117 / c-kit Protein, Fc Tag (MALS verified), Unconjugated, Human
• Biozol Catalog Number: ABS-CD7-M5259-100UG
• Supplier Catalog Number: CD7-M5259-100ug
• Alternative Catalog Number: ABS-CD7-M5259-100UG
• Manufacturer: AcroBiosystems
• Host: Human
• Category: Proteine/Peptide
• Species Reactivity: Mouse
• Conjugation: Unconjugated

Product Description

Mast/stem cell growth factor receptor Kit (cKit), a member of the protein kinase superfamily, Tyr protein kinase family and CSF1/PDGF receptor subfamily, is also known as piebald trait protein (PBT), p145 ckit, tyrosineprotein kinase Kit and CD117,which contains five Iglike C2type (immunoglobulinlike) domains and one protein kinase domain. CD117 acts as cellsurface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, CD117 can activate several signaling pathways. Furthermore, Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. - Proteine/Peptide

Product Properties

• Molecular Weight: 81.5 kDa
• Tag: C-Fc
• NCBI: 05532
• Buffer: 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5
• Purity: 95%
• Form: Powder
• Target: CD117

Images

Immobilized Human SCF protein, His Tag at 2 µg/mL (100 µL/well) can bind Mouse CD117, Fc Tag (Cat. No. CD7-M5259) with a linear range of 0.078-5 µg/mL (QC tested).

Mouse CD117, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.