Biotinylated Human CD89 / FCAR Protein, His,Avitag(TM) (MALS verified)
Biozol Catalog Number:
ABS-CD9-H82EB-25UG
Supplier Catalog Number:
CD9-H82Eb-25ug
Alternative Catalog Number:
ABS-CD9-H82EB-25UG
Manufacturer:
AcroBiosystems
Host:
Human
Category:
Proteine/Peptide
Species Reactivity:
Human
Conjugation:
Biotin
CD89 (FCAR) is a variably glycosylated 50100 kDa myeloidspecific type I transmembrane (TM) Fc receptor for IgA that is a member of the multichain immune recognition receptor (MIRR) family. Human CD89 contains a 21 amino acid (aa) signal sequence and extracellular (ECD), TM and cytoplasmic domains of 206, 19 and 41 aa, respectively. Arg230 within the TM domain supports interaction with the ITAMcontaining signaling subunit, FcR gamma, which contains a TM Asp . Two ECD C2type Iglike domains (EC1 and 2) are oriented at right angles. Up to two molecules of FCAR can bind one molecule of serum IgA via EC1. Many splice variants have been reported, but only two have been identified as proteins. The a.2 form, which lacks 22 aa just prior to the TM domain, is exclusively expressed in alveolar macrophages. The a.3 form lacks EC2. FCAR binds monomeric, polymeric and secretory IgA, but does not mediate the barrier function of secretory IgA in mucosal epithelium. CD89 (Fc alphaRI) is the human myeloid IgA Fc receptor expressed on cells, such as neutrophils, eosinophils and monocytes/macrophages. Crosslinking of CD89 on these cells, by IgAopsonised particles (e.g. bacteria, viruses) or antiCD89 monoclonal antibodies, can trigger various immunological effector functions which are generally protective but may also cause harm to the body. - Proteine/Peptide
Immobilized Human Anti-VP1 (NoV)-antibody-NORO-320, Human IgA2
Biotinylated Human CD89 Protein, His,Avitag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
* VAT and and shipping costs not included. Errors and price changes excepted
