Human Fc gamma RIIIA / CD16a (F176) Protein, His Tag (MALS & SPR verified), Unconjugated
Biozol Catalog Number:
ABS-CDA-H5220-1MG
Supplier Catalog Number:
CDA-H5220-1mg
Alternative Catalog Number:
ABS-CDA-H5220-1MG
Manufacturer:
AcroBiosystems
Host:
Human
Category:
Proteine/Peptide
Species Reactivity:
Human
Conjugation:
Unconjugated
CD16 is a low affinity Fc receptor, and has been identified as Fc receptors FcgammaRIIIa (CD16a) and FcgammaRIIIb (CD16b). These receptors bind to the Fc portion of IgG antibodies. CD16 encoded by two different highly homologous genes in a cell typespecific manner.CD16 is found on the surface of natural killer cells, neutrophil polymorphonuclear leukocytes, monocytes and macrophages. CD16a antigen is also known as Low affinity immunoglobulin gamma Fc region receptor IIIA, Fcgamma RIIIalpha. CD16b is a lowaffinity, GPIlinked receptor expressed by neutrophils and eosinophils, whereas CD16a is an intermediate affinity polypeptideanchored transmembrane glycoprotein expressed natural killer cells, macrophages, subpopulation of Tcells, immature thymocytes and placentaltrophoblasts.CD16a is involved in phagocytosis, secretion of enzymes and inflammatory mediators, antibodydependent cytotoxicity and clearance of immune complexes. Aberrant expression or mutations of CD16a is implicated in susceptibility to recurrent viral infections, systemic lupus erythematosus, and alloimmune neonatal neutropenia. - Proteine/Peptide
