Human CD3 gamma / CD3G Protein, Fc Tag (MALS verified), Unconjugated
Biozol Catalog Number:
ABS-CDA-H5254-100UG
Supplier Catalog Number:
CDA-H5254-100ug
Alternative Catalog Number:
ABS-CDA-H5254-100UG
Manufacturer:
AcroBiosystems
Host:
Human
Category:
Proteine/Peptide
Species Reactivity:
Human
Conjugation:
Unconjugated
CD3 gamma chain is part of the TCRCD3 complex present on Tlymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate Tcell receptor (TCR), TCRmediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosinebased activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition to this role of signal transduction in Tcell activation, CD3G plays an essential role in the dynamic regulation of TCR expression at the cell surface. Indeed, constitutive TCR cycling is dependent on the dileucinebased (diL) receptorsorting motif present in CD3G. - Proteine/Peptide
Human CD3 gamma, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
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