Mouse CFH Protein, His Tag (MALS verified), Unconjugated, Human
Biozol Catalog Number:
ABS-CFH-M52H3-1MG
Supplier Catalog Number:
CFH-M52H3-1mg
Alternative Catalog Number:
ABS-CFH-M52H3-1MG
Manufacturer:
AcroBiosystems
Host:
Human
Category:
Proteine/Peptide
Species Reactivity:
Mouse
Conjugation:
Unconjugated
Complement Factor H (CFH) composed of 20 repetitive units of 60 amino acids, named short consensus repeats (SCR) or complement control protein modules (CCP), arranged in a continuous fashion. CFH is amongst the most abundant complement components in human blood, where the liver is the major source of CFH protein in vivo. The CFH molecule includes different interaction sites for C3b and polyanions which delineate distinct functional domains at the N and Ctermini. The C3b binding site in SCR14 is the only site essential for the factor I cofactor activity of factor H. Similarly, the C3b/polyanionsbinding site located within SCR1920 is the most important site for preventing alternative pathway activation on host cells. Mutations in the CFH gene are associated with severe and diverse diseases including the rare renal disorders hemolytic uremic syndrome (HUS) and membranoproliferative (MPGN) also termed dense deposit disease (DDD), as well as the more frequent retinal disease age related macular degeneration (AMD). - Proteine/Peptide
Immobilized Mouse CFH Protein, His Tag (Cat. No. CFH-M52H3) at 5 µg/mL (100 µL/well) can bind Heparin Biotin with a linear range of 0.078-5 µg/mL (QC tested).
Mouse CFH Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
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