NY-ESO-1 specific TCR-HEK293 cell line, Human 2 Vials Preis auf Anfrage
Biozol Catalog Number:
ABS-CHEK-STP114-2VIALS
Supplier Catalog Number:
CHEK-STP114-2Vials
Alternative Catalog Number:
ABS-CHEK-STP114-2VIALS
Manufacturer:
AcroBiosystems
Host:
Human
Category:
Zellen/Zellkultur
Species Reactivity:
Human
Cluster of Differentiation 3 (CD3) is a pivotal multimeric T cell coreceptor complex essential for adaptive immune responses. Composed of epsilon (epsilon), gamma (gamma), delta (delta), and zeta (zeta) polypeptide chains forming three distinct dimers (epsilongamma, epsilondelta, zetazeta), CD3 noncovalently associates with the Tcell receptor (TCR) to establish the critical TCR/CD3 receptor complex on T cell surfaces. Structurally, CD3 proteins belong to the immunoglobulin superfamily, featuring a transmembrane domain, an Nterminal extracellular region with immunoglobulinlike domains, and cytoplasmic tails embedded with immunoreceptor tyrosinebased activation motifs (ITAMs). These ITAMs are fundamental for initiating signal transduction upon T cell receptor engagement, thereby activating both CD4+ T helper and CD8+ cytotoxic T cells. As a defining marker of the T cell lineage, CD3s central role in T cell activation makes its modulation, via stimulating or blocking antibodies, a promising therapeutic avenue for conditions like organ transplant rejection and autoimmune diseases. - Zellen/Zellkultur
Tag:
Native
Form:
Liquid
Target:
NY-ESO-1
Application Notes:
Binding assay by FACS and cell based ELISA.
CHEK-STP114-2Vials
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