Mouse Claudin-18.2 Full Length Protein (VLP), Unconjugated, Human 20 ug
Biozol Catalog Number:
ABS-CL2-M52P3-20UG
Supplier Catalog Number:
CL2-M52P3-20ug
Alternative Catalog Number:
ABS-CL2-M52P3-20UG
Manufacturer:
AcroBiosystems
Host:
Human
Category:
Proteine/Peptide
Species Reactivity:
Mouse
Conjugation:
Unconjugated
Involved in alveolar fluid homeostasis via regulation of alveolar epithelial tight junction composition and therefore ion transport and solute permeability, potentially via downstream regulation of the actin cytoskeleton organization and beta2adrenergic signaling. Required for lung alveolarization and maintenance of the paracellular alveolar epithelial barrier. Acts to maintain epithelial progenitor cell proliferation and organ size, via regulation of YAP1 localization away from the nucleus and thereby restriction of YAP1 target gene transcription. Acts as a negative regulator of RANKLinduced osteoclast differentiation, potentially via relocation of TJP2/ZO2 away from the nucleus, subsequently involved in bone resorption in response to calcium deficiency. Mediates the osteoprotective effects of estrogen, potentially via acting downstream of estrogen signaling independently of RANKL signaling pathways. Required for the formation of the gastric paracellular barrier via its role in tight junction formation, thereby involved in the response to gastric acidification. - Proteine/Peptide
Immobilized Mouse Claudin-18.2 Full Length Protein (VLP) (Cat. No. CL2-M52P3) at 5 µg/mL (100 µL/well) can bind Monoclonal Anti-Chimeric Claudin-18.2 Antibody with a linear range of 0.2-3 ng/mL (QC tested).
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