Lectin that functions as pattern recognizing receptor (PRR) specific for beta1,3linked and beta1,6linked glucans, which constitute cell wall constituents from pathogenic bacteria and fungi (PubMed:11567029, PubMed:12423684). Necessary for the TLR2mediated inflammatory response and activation of NFkappaB: upon betaglucan binding, recruits SYK via its ITAM motif and promotes a signaling cascade that activates some CARD domainBCL10MALT1 (CBM) signalosomes, leading to the activation of NFkappaB and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding proinflammatory cytokines and chemokines (By similarity). Enhances cytokine production in macrophages and dendritic cells (By similarity). Mediates production of reactive oxygen species in the cell (By similarity). Mediates phagocytosis of C.albicans conidia (PubMed:17230442). Binds Tcells in a way that does not involve their surface glycans and plays a role in Tcell activation. Stimulates Tcell proliferation. Induces phosphorylation of SCIMP after binding betaglucans (By similarity). - Proteine/Peptide
Human CLEC7A Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.
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