Human Claudin-9 / CLDN9 Full Length Protein, His,Twin-Strep Tag (Nanodisc), Unconjugated, Insect
Biozol Catalog Number:
ABS-CL9-H5283-100UG
Supplier Catalog Number:
CL9-H5283-100ug
Alternative Catalog Number:
ABS-CL9-H5283-100UG
Manufacturer:
AcroBiosystems
Host:
Insect
Category:
Proteine/Peptide
Species Reactivity:
Human
Conjugation:
Unconjugated
Claudin9 belongs to the claudin family. Claudins constitute integral membrane proteins responsible for solute and electrolyte permeability of the tight junction that serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Tight junctions also play a critical role in maintaining cell polarity and signal transductions. Claudin9 creates charge specific channels in the paracellular space, plays a major role in tight junctionspecific obliteration of the intercellular space, through calciumindependent celladhesion activity, is required to preserve sensory cells in the hearing organ because claudin9defective tight junctions fail to shield the basolateral side of hair cells from the K+rich endolymph. Its ion barrier function is essential in the cochlea, but appears to be dispensable in other organs. Is one of the entry cofactors for hepatitis C virus, it enables HCV entry into target cells just as efficiently as CLDN1. - Proteine/Peptide
