Human Complement C5 Protein, His Tag, low endotoxin (MALS verified), Unconjugated
Biozol Catalog Number:
ABS-CO5-H52HA-1MG
Supplier Catalog Number:
CO5-H52Ha-1mg
Alternative Catalog Number:
ABS-CO5-H52HA-1MG
Manufacturer:
AcroBiosystems
Host:
Human
Category:
Proteine/Peptide
Species Reactivity:
Human
Conjugation:
Unconjugated
Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. C5 precursor is first processed by the removal of 4 basic residues, forming two chains, beta and alpha, linked by a disulfide bond. C5 convertase activates C5 by cleaving the alpha chain, releasing C5a anaphylatoxin and generating C5b (beta chain + alpha chain). Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5bC6 complex is the foundation upon which the lytic complex is assembled. The C5a anaphylatoxin interacts with C5AR1 and tick complement inhibitor. C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation. - Proteine/Peptide
Molecular Weight:
73.9 kDa (beta chain) & 114.4 kDa (alpha chain)
Immobilized Human ComplementC5, His Tag (Cat. No. CO5-H52Ha) at 2 µg/mL (100 µL/well) can bind Anti-C5a (Human IgG1) with a linear range of 0.2-3 ng/mL (QC tested).
Immobilized Human Complement C5, His Tag (Cat. No. CO5-H52Ha) at 2 µg/mL (100 µL/well) can bind EculizumabBiosimilar with a linear range of 0.1-4 ng/mL (Routinely tested).
Human Complement C5, His Tag on SDS-PAGE under reducing (R) and under non-reducing (NR) conditions. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.
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