Rat Complement C5 Protein, His Tag, Unconjugated, Human
Biozol Catalog Number:
ABS-CO5-R52H5-1MG
Supplier Catalog Number:
CO5-R52H5-1mg
Alternative Catalog Number:
ABS-CO5-R52H5-1MG
Manufacturer:
AcroBiosystems
Host:
Human
Category:
Proteine/Peptide
Species Reactivity:
Rat
Conjugation:
Unconjugated
Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. C5 precursor is first processed by the removal of 4 basic residues, forming two chains, beta and alpha, linked by a disulfide bond. C5 convertase activates C5 by cleaving the alpha chain, releasing C5a anaphylatoxin and generating C5b (beta chain + alpha chain). Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5bC6 complex is the foundation upon which the lytic complex is assembled. The C5a anaphylatoxin interacts with C5AR1 and tick complement inhibitor. C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation. - Proteine/Peptide
Molecular Weight:
74.1 kDa (beta chain) & 114.8 kDa (alpha chain)
