Human M-CSF R / CSF1R / CD115 Protein, Mouse IgG2a Fc Tag (MALS verified), Unconjugated
Biozol Catalog Number:
ABS-CSR-H5255-100UG
Supplier Catalog Number:
CSR-H5255-100ug
Alternative Catalog Number:
ABS-CSR-H5255-100UG
Manufacturer:
AcroBiosystems
Host:
Human
Category:
Proteine/Peptide
Species Reactivity:
Human
Conjugation:
Unconjugated
Colony stimulating factor 1 receptor (CSF1R) is also known as macrophage colonystimulating factor receptor (MCSFR), CD115 Cluster of Differentiation 115 (CD115), CFMS, CSFR, FIM2, FMS, and is a member of the typeIII subfamily of receptor tyrosine kinases (RTKs). CSF1R is a receptor for a cytokine called colony stimulating factor 1, The protein encoded by the CSFR1 gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most, if not all, of the biological effects of this cytokine. Ligand binding activates CSFR1 through a process of oligomerization and transphosphorylation . Mutations in CSF1R are associated with chronic myelomonocytic leukemia and type M4 acute myeloblastic leukemia. Increased levels of CSF1R1 are found in microglia in Alzheimers disease and after brain injuries. The increased receptor expression causes microglia to become more active. Both CSF1R, and its ligand colony stimulating factor 1 play an important role in the development of the mammary gland and may be involved in the process of mammary gland carcinogenesis. - Proteine/Peptide
