Human CXCR2 Full Length Protein (VLP), Unconjugated
Biozol Catalog Number:
ABS-CX2-H52P4-100UG
Supplier Catalog Number:
CX2-H52P4-100ug
Alternative Catalog Number:
ABS-CX2-H52P4-100UG
Manufacturer:
AcroBiosystems
Host:
Human
Category:
Proteine/Peptide
Species Reactivity:
Human
Conjugation:
Unconjugated
The protein encoded by this gene is a member of the Gproteincoupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a Gprotein activated second messenger system. This receptor also binds to chemokine (CXC motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serumdependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33q36. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009] - Proteine/Peptide
Immobilized Human CXCR2 Full Length Protein (VLP) (Cat. No. CX2-H52P4) at 5 µg/mL (100 µL/well) can bind Anti-CXCR2Antibody with a linear range of 1-8 ng/mL (QC tested).
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