Human CXCR3 Protein, Flag,His Tag (Detergent), Unconjugated

Product Overview

• Article Name: Human CXCR3 Protein, Flag,His Tag (Detergent), Unconjugated
• Biozol Catalog Number: ABS-CX3-H52D5-100UG
• Supplier Catalog Number: CX3-H52D5-100ug
• Alternative Catalog Number: ABS-CX3-H52D5-100UG
• Manufacturer: AcroBiosystems
• Host: Human
• Category: Proteine/Peptide
• Species Reactivity: Human
• Conjugation: Unconjugated

Product Description

Chemokines are proteins which induce chemotaxis, promote differentiation of immune cells, and cause tissue extravasation. Given these properties, their role in antitumor immune response in the cancer environment is of great interest. Although immunotherapy has shown clinical benefit for some cancer patients, other patients do not respond. One of the mechanisms of resistance to checkpoint inhibitors may be chemokine signaling. The CXCL9, 10, 11/CXCR3 axis regulates immune cell migration, differentiation, and activation, leading to tumor suppression (paracrine axis). However, there are some reports that show involvements of this axis in tumor growth and metastasis (autocrine axis). Thus, a better understanding of CXCL9, 10, 11/CXCR3 axis is necessary to develop effective cancer control. - Proteine/Peptide

Product Properties

• Molecular Weight: 43.5 kDa
• Tag: N-Flag & C-6*His
• NCBI: 49682
• Buffer: 50 mM HEPES, 150 mM NaCl, DDM, CHS, pH7.5
• Form: Liquid
• Target: CXCR3

Images

Immobilized Human CXCR3 Protein, Flag,His Tag (Cat. No. CX3-H52D5) at 1 µg/mL (100 µL/well) can bind Anti-CXCR3 Antibody, Human IgG1 with a linear range of 0.03-1 ng/mL (QC tested).