Human CXCR6 / CD186 Full Length Protein (VLP), Unconjugated
Biozol Catalog Number:
ABS-CX6-H52P3-20UG
Supplier Catalog Number:
CX6-H52P3-20ug
Alternative Catalog Number:
ABS-CX6-H52P3-20UG
Manufacturer:
AcroBiosystems
Host:
Human
Category:
Proteine/Peptide
Species Reactivity:
Human
Conjugation:
Unconjugated
The protein encoded by this gene is a G proteincoupled receptor with seven transmembrane domains that belongs to the CXC chemokine receptor family. This family also includes CXCR1, CXCR2, CXCR3, CXCR4, CXCR5, and CXCR7. This gene, which maps to the chemokine receptor gene cluster, is expressed in several T lymphocyte subsets and bone marrow stromal cells. The encoded protein and its exclusive ligand, chemokine ligand 16 (CCL16), are part of a signalling pathway that regulates T lymphocyte migration to various peripheral tissues (the liver, spleen red pulp, intestine, lungs, and skin) and promotes cellcell interaction with dendritic cells and fibroblastic reticular cells. CXCR6/CCL16 also controls the localization of resident memory T lymphocytes to different compartments of the lung and maintains airway resident memory T lymphocytes, which are an important first line of defense against respiratory pathogens. The encoded protein serves as an entry coreceptor used by HIV1 and SIV to enter target cells, in conjunction with CD4. [provided by RefSeq, Aug 2020] - Proteine/Peptide
Immobilized Human CXCR6 Full Length Protein (VLP) (Cat. No. CX6-H52P3) at 5 µg/mL (100 µL/well) can bind Monoclonal Anti-HumanCXCR6antibody, Mouse IgG with a linear range of 1-16 ng/mL (QC tested).
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