Monoclonal Anti-DM-1 Antibody, Rabbit IgG (M5D04), Unconjugated, Human
Biozol Catalog Number:
ABS-DM1-MY2358-1MG
Supplier Catalog Number:
DM1-MY2358-1mg
Alternative Catalog Number:
ABS-DM1-MY2358-1MG
Manufacturer:
AcroBiosystems
Host:
Human
Category:
Antikörper
Species Reactivity:
Rabbit
Conjugation:
Unconjugated
DM1, a maytansinoid derivative, is a common payload toxin in antibodydrug conjugates (ADCs). It binds to tubulin, hinders microtubule assembly, arrests cell division, and induces apoptosis, but has offtarget toxicity. ADCs like TDM1 have shown good efficacy in HER2positive cancers. For recent progress, many new DM1containing ADCs are under development. For example, GQ1001 has entered Phase I clinical trials for HER2+ advanced solid tumors, and some have demonstrated antitumor activity in TDM1resistant models in preclinical studies. - Antikörper
Tag:
Rabbit IgG | Rabbit Kappa
Buffer:
PBS, pH7.4
Form:
Powder
Target:
DM-1
Immobilized Monoclonal Anti-DM-1 Antibody, Rabbit IgG (M5D04) (Cat. No. DM1-MY2358) at 5 µg/mL, add DM1 Antibody Human IgG in the 100% Human Serum and then add Biotinylated Human Her2, His,Avitag, premium grade (Cat. No. HE2-H82E2) at 0.5 µg/mL. Detection was performed using HRP-conjugated Streptavidin (Acro, Cat. No. STN-NH913) (QC tested).
Immobilized Monoclonal Anti-DM-1 Antibody, Rabbit IgG (M5D04) (Cat. No. DM1-MY2358) at 1 µg/mL (100 µL/well) can bind DM1 Antibody Human IgG with a linear range of 0.004-0.125 µg/mL (Routinely tested).
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