Mertansine (DM1) is a tubulin inhibitor that binds to the ends of microtubules and inhibits microtubule dynamics. DM1(Mertansine) has antitumor activity and functions as a regulator of tubulin. It is an alphaamino acid ester, a carbamate, an epoxide, an organic heterocyclic tetracyclic compound, an organochlorine compound, a mercaptan, and a maydenin alkaloid. DM1, derived from Mydenin, is a cytotoxic component of antibodydrug conjugations that produce antibodydrug conjugations via a sulfhydryl group splice with SPP (nsuccinimide 4 (2pyridyl dithio)) or SMCC (4 (3mercapto2, 5dioxy1 pyrrolidyl) cyclohexanic acid) splice. - Antikörper
Tag:
Mouse IgG1 | Mouse Kappa
Buffer:
PBS, pH7.4
Form:
Powder
Target:
DM-1
Immobilized Monoclonal Anti-DM-1&DM-4 Antibody, Mouse IgG1 (Cat. No. DM1-Y73) at 5 µg/mL, add Trastuzumab-DM1 in the 50% Human serum and then add Biotinylated Human Her2, His,Avitag, premium grade (Cat. No. HE2-H82E2) at 0.5 µg/mL. Detection was performed using HRP-conjugated Streptavidin (Acro, Cat. No. STN-NH913) (QC tested).
Immobilized ADC-DM4 at 2 µg/mL (100 µL/well) can bind Monoclonal Anti-DM-1&DM-4 Antibody, Mouse IgG1 (Cat. No. DM1-Y73) with a linear range of 0.20-6.25ng/mL (Routinely tested).
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