Monoclonal Anti-DXD&Exatecan Antibody, Mouse IgG1, Unconjugated, Human
Biozol Catalog Number:
ABS-DXD-M684-1MG
Supplier Catalog Number:
DXD-M684-1mg
Alternative Catalog Number:
ABS-DXD-M684-1MG
Manufacturer:
AcroBiosystems
Host:
Human
Category:
Antikörper
Species Reactivity:
Mouse
Conjugation:
Unconjugated
Dxd (Exatecan ADC derivative) is a potent DNA topoisomerase I inhibitor with an IC50 of 0.31 uM for targeting ADCs (DS8201A). Dxd was cytotoxic to human tumor cell lines KPL4, NCIN87 and SKBR, 3 and the IC50s of MDAMB468 was 1.43 NM4.07 nM, while lgGADC (Dxd as payload) had no inhibitory effect on HER2 expression in the 4 cell lines. DS8201a (Dxd as payload) had a significant inhibitory effect on HER2positive KPL4 and NCI cell lines N87 and SKBRwith IC50 values of 26.8, 25.4 and 6.7 ng/mL, respectively, but had no inhibitory effect on MDA MB468 (IC50, > 10000 mL). HRPantiDXDantibody is a conjugation product of HRP and antiDXDantibody. It can be used in PK, PD analysis and ELISA. - Antikörper
Tag:
Mouse IgG1 | Mouse kappa
Buffer:
PBS, pH7.4
Form:
Powder
Target:
DXD
Immobilized Mouse Anti-DXD&Exatecan Antibody, Mouse IgG1, mAb (Cat. No. DXD-M684) at 1 µg/mL, add Trastuzumab deruxtecan in the 50% Human serum and then add Biotinylated Human Her2, His,Avitag, premium grade (Cat. No. HE2-H82E2) at 0.5 µg/mL. Detection was performed using HRP-conjugated Streptavidin (Acro, Cat. No. STN-NH913) (QC tested).
Immobilized Trastuzumab Deruxtecan at 1 µg/mL (100 µL/well) can bind Monoclonal Anti-DXD&Exatecan Antibody, Mouse IgG1 (Cat. No. DXD-M684) with a linear range of 0.1-4 ng/mL (Routinely tested).
DXD-M684-1mg
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