Monoclonal Anti-DXD & Exatecan Antibody, Rabbit IgG (M1B09), Unconjugated, Human
Biozol Catalog Number:
ABS-DXD-MY2290-1MG
Supplier Catalog Number:
DXD-MY2290-1mg
Alternative Catalog Number:
ABS-DXD-MY2290-1MG
Manufacturer:
AcroBiosystems
Host:
Human
Category:
Antikörper
Species Reactivity:
Rabbit
Conjugation:
Unconjugated
Dxd (Exatecan ADC derivative) is a potent DNA topoisomerase I inhibitor with an IC50 of 0.31 uM for targeting ADCs (DS8201A). Dxd was cytotoxic to human tumor cell lines KPL4, NCIN87 and SKBR, 3 and the IC50s of MDAMB468 was 1.43 NM4.07 nM, while lgGADC (Dxd as payload) had no inhibitory effect on HER2 expression in the 4 cell lines. DS8201a (Dxd as payload) had a significant inhibitory effect on HER2positive KPL4 and NCI cell lines N87 and SKBRwith IC50 values of 26.8, 25.4 and 6.7 ng/mL, respectively, but had no inhibitory effect on MDA MB468 (IC50, > 10000 mL). HRPantiDXDantibody is a conjugation product of HRP and antiDXDantibody. It can be used in PK, PD analysis and ELISA. - Antikörper
Tag:
Rabbit IgG | Rabbit Kappa
Buffer:
PBS, pH7.4
Form:
Powder
Target:
DXD & Exatecan
Immobilized Monoclonal Anti-DXD & Exatecan Antibody, Rabbit IgG (M1B09) (Cat. No. DXD-MY2290) at 5 µg/mL, add Trastuzumab Deruxtecan in the 100% Human Serum and then add Biotinylated Human Her2, His,Avitag, premium grade (Cat. No. HE2-H82E2) at 0.5 µg/mL. Detection was performed using HRP-conjugated Streptavidin (Acro, Cat. No. STN-NH913) (QC tested).
Immobilized Monoclonal Anti-DXD & Exatecan Antibody, Rabbit IgG (M1B09) (Cat. No. DXD-MY2290) at 5 µg/mL, add Trastuzumab Deruxtecan in the 0.5% BSA and then add Biotinylated Human Her2, His,Avitag, premium grade (Cat. No. HE2-H82E2) at 0.5 µg/mL. Detection was performed using HRP-conjugated Streptavidin (Acro, Cat. No. STN-NH913) (Routinely tested).
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