HRP conjugated Monoclonal Anti-DXD&Exatecan Antibody, Mouse IgG1, Human
Biozol Catalog Number:
ABS-DXD-PLM684-200UG
Supplier Catalog Number:
DXD-PLM684-200ug
Alternative Catalog Number:
ABS-DXD-PLM684-200UG
Manufacturer:
AcroBiosystems
Host:
Human
Category:
Antikörper
Species Reactivity:
Mouse
Conjugation:
HRP
Dxd (Exatecan ADC derivative) is a potent DNA topoisomerase I inhibitor with an IC50 of 0.31 uM for targeting ADCs (DS8201A). Dxd was cytotoxic to human tumor cell lines KPL4, NCIN87 and SKBR, 3 and the IC50s of MDAMB468 was 1.43 NM4.07 nM, while lgGADC (Dxd as payload) had no inhibitory effect on HER2 expression in the 4 cell lines. DS8201a (Dxd as payload) had a significant inhibitory effect on HER2positive KPL4 and NCI cell lines N87 and SKBRwith IC50 values of 26.8, 25.4 and 6.7 ng/mL, respectively, but had no inhibitory effect on MDA MB468 (IC50, > 10000 mL). HRPantiDXDantibody is a conjugation product of HRP and antiDXDantibody. It can be used in PK, PD analysis and ELISA. - Antikörper
Tag:
Mouse IgG1 | Mouse kappa
Buffer:
PBS, pH7.4
Form:
Powder
Target:
DXD
Immobilized Human Her2, His Tag (Cat. No. HE2-H5225) at 1 µg/mL, add Trastuzumab Deruxtecan in the 100% Human Serum and then add HRP conjugated Monoclonal Anti-DXD&Exatecan Antibody, Mouse IgG1 (Cat. No. DXD-PLM684) at 0.1 µg/mL (QC tested).
Immobilized Trastuzumab-Exatecan at 1 µg/mL (100 µL/well) can bind HRP conjugated Mouse Anti-DXD&Exatecan Antibody, Mouse IgG1 (Cat. No. DXD-PLM684) with a linear range of 1-16 ng/mL (Routinely tested).
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