Human EDNRB Full Length Protein (VLP), Unconjugated
Biozol Catalog Number:
ABS-EDB-H52P7-100UG
Supplier Catalog Number:
EDB-H52P7-100ug
Alternative Catalog Number:
ABS-EDB-H52P7-100UG
Manufacturer:
AcroBiosystems
Host:
Human
Category:
Proteine/Peptide
Species Reactivity:
Human
Conjugation:
Unconjugated
Endothelin Receptor B (EDNRB) is a type of G proteincoupled Receptor with the Nterminus located outside the cell. Its widespread in the human body. EDNRB binds to ET and transmits information into the cell through the intracellular Ca2+ phospholipiddependent protein kinase second messenger system, which promotes the rapid release of calcium in the endoplasmic reticulum and sarcoplasmic reticulum, resulting in the rapid increase of intracellular calcium concentration. Endothelin exerts its biological effects through its receptor (ETR). Endothelin and ETR constitute the endothelin axis. Endothelin axis has protumor effects in various tumors including malignant melanoma (MM), including promoting tumor growth, antiapoptosis, promoting angiogenesis and promoting tumor metastasis. - Proteine/Peptide
