Human EGFRvIII Protein, His Tag (MALS verified), Unconjugated

Product Overview

• Article Name: Human EGFRvIII Protein, His Tag (MALS verified), Unconjugated
• Biozol Catalog Number: ABS-EGI-H52H4-1MG
• Supplier Catalog Number: EGI-H52H4-1mg
• Alternative Catalog Number: ABS-EGI-H52H4-1MG
• Manufacturer: AcroBiosystems
• Host: Human
• Category: Proteine/Peptide
• Species Reactivity: Human
• Conjugation: Unconjugated

Product Description

The epidermal growth factor receptor (EGFR, ErbB1, HER1 in humans) is the cellsurface receptor for members of the epidermal growth factor family (EGFfamily) of extracellular protein ligands. The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB1), HER2/cneu (ErbB2), Her 3 (ErbB3) and Her 4 (ErbB4). Mutations affecting EGFR expression or activity could result in cancer. The type III EGF deletion mutant receptor (EGFRvIII) is the most common mutation and was first identified in primary human glioblastoma tumors. This tumorspecific antigen is ligandindependent, contains a constitutively active tyrosine kinase domain, and has been shown to be present in a number of human malignancies. EGFRvIII has been selected as a target for CARmodified Tcell studies in recent years. - Proteine/Peptide

Product Properties

• Molecular Weight: 40.5 kDa
• Tag: C-10*His
• NCBI: 001333870
• Buffer: PBS, pH7.4
• Purity: 95%
• Form: Powder
• Target: EGFRvIII

Images

Immobilized Human EGFRvIII, His Tag (Cat. No. EGI-H52H4) at 1 µg/mL (100 µL/well) can bind Anti-EGFRvIII Antibody , Human IgG1 with a linear range of 0.1-2 ng/mL (QC tested).

Immobilized Human EGFRvIII, His Tag (Cat. No. EGI-H52H4) at 1 µg/mL (100 µL/well) can bind Cetuximab with a linear range of 0.1-1 ng/mL (Routinely tested).

EGI-H52H4-1mg

Human EGFRvIII, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.