Biotinylated Human EGFRvIII Protein, His,Avitag(TM) (MALS verified)
Biozol Catalog Number:
ABS-EGR-H82E0-25UG
Supplier Catalog Number:
EGR-H82E0-25ug
Alternative Catalog Number:
ABS-EGR-H82E0-25UG
Manufacturer:
AcroBiosystems
Host:
Human
Category:
Proteine/Peptide
Species Reactivity:
Human
Conjugation:
Biotin
The epidermal growth factor receptor (EGFR, ErbB1, HER1 in humans) is the cellsurface receptor for members of the epidermal growth factor family (EGFfamily) of extracellular protein ligands. The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB1), HER2/cneu (ErbB2), Her 3 (ErbB3) and Her 4 (ErbB4). Mutations affecting EGFR expression or activity could result in cancer. The type III EGF deletion mutant receptor (EGFRvIII) is the most common mutation and was first identified in primary human glioblastoma tumors. This tumorspecific antigen is ligandindependent, contains a constitutively active tyrosine kinase domain, and has been shown to be present in a number of human malignancies. EGFRvIII has been selected as a target for CARmodified Tcell studies in recent years. - Proteine/Peptide
Immobilized Biotinylated Human EGFRvIII, His,Avitag (Cat. No. EGR-H82E0) at 1 µg/mL (100 µL/well) on streptavidin (Cat. No. STN-N5116) precoated (0.5 µg/well) plate can bind Anti-EGFRvIII Antibody, Human IgG1 with a linear range of 0.1-3 ng/mL (QC tested).
Immobilized CetuxiMab at 1 µg/mL (100 µL/well) can bind Biotinylated Human EGFRvIII, His,Avitag (Cat. No. EGR-H82E0) with a linear range of 0.2-2 ng/mL (Routinely tested).
Biotinylated Human EGFRvIII, His,Avitag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
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