Human ENPP3 / CD203c Protein, Fc Tag (active enzyme, MALS verified), Unconjugated

Product Overview

• Article Name: Human ENPP3 / CD203c Protein, Fc Tag (active enzyme, MALS verified), Unconjugated
• Biozol Catalog Number: ABS-EN3-H5267-100UG
• Supplier Catalog Number: EN3-H5267-100ug
• Alternative Catalog Number: ABS-EN3-H5267-100UG
• Manufacturer: AcroBiosystems
• Host: Human
• Category: Proteine/Peptide
• Species Reactivity: Human
• Conjugation: Unconjugated

Product Description

The human NPP family contains seven members which can be classified into two groups according to their substrate preferences. The first class comprises the nucleotidedegrading proteins NPP1, 3 and 4. NPP3 (CD203c, ENPP3) is expressed in multiple organs, including on epithelial and mucosal surfaces, and notably on basophils and mast cells. Activation of basophils by antigenbound IgE leads to release of inflammatory mediators and rapid upregulation of NPP3 to the cell surface. This protein is in fact a common marker for diagnosing allergen sensitivity with patient basophils by flow cytometry. Basophils and mast cells mediate the response to certain pathogens, as well as acute and chronic allergic reactions. Following activation, these cells release ATP, which further stimulates them in an autocrine manner. NPP3 upregulation serves to degrade ATP and suppress chronic allergic inflammation (but not the acute response). - Proteine/Peptide

Product Properties

• Molecular Weight: 121.5 kDa
• Tag: N-Fc
• NCBI: 14638
• Buffer: 50 mM Tris, 150 mM NaCl, pH7.5
• Purity: 90%
• Form: Powder
• Target: ENPP3

Images

Human ENPP3 Protein, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.