Receptor tyrosine kinase which binds promiscuously membranebound ephrinA family ligands residing on adjacent cells, leading to contactdependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrinA1/EFNA1 regulates migration, integrinmediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. Engaged by the ligand ephrinA5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrinA2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis. - Proteine/Peptide
Immobilized Human EphA4, His Tag (Cat. No. EP4-H52H8) at 5 µg/mL (100 µL/well) can bind Human Ephrin-A4, Fc Tag (Cat. No. EA4-H5250) with a linear range of 0.6-5 ng/mL (QC tested).
Human EphA4, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
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