EpCAM is also known as CO171A, EGP, EGP40,GA7332, KSA, M4S, MIC18, MK1, TROP1, hEGP2, and is a panepithelial differentiation antigen that is expressed on almost all carcinomas as 171A(mAb) antigen. Its constitutional function is being elucidated. It is intricately linked with the CadherinCatenin pathway and hence the fundamental WNT pathway responsible for intracellular signaling and polarity. The epithelial cell adhesion molecule (EpCAM) is known to express in most epithelial malignancies and was reported as a tumor marker or a candidate of molecular targeting therapy. EpCAM cross signaling with Ncadherin involves Pi3K, resulting in the abrogation of the cadherin adhesion complexes in epithelial cells was reported. And Epithelial cell adhesion molecule (EpCAM) recently received increased attention as a prognostic factor in breast cancer. - Proteine/Peptide
Immobilized Anti-EpCAM Antibody, Human IgG1 at 1 µg/mL (100 µL/well) can bind FITC-Labeled Human EpCAM, His Tag (Cat. No. EPM-HF225) with a linear range of 0.01-0.313 µg/mL (QC tested).
FITC-Labeled Human EpCAM, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.
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