CD8a is a 3234 kD type I glycoprotein. It forms a homodimer (CD8a/a) or heterodimer (CD8a/b) with CD8b. CD8, also known as T8 and Leu2, is a member of the immunoglobulin superfamily found on the majority of thymocytes, a subset of peripheral blood T cells, and NK cells (which express almost exclusively CD8a homodimers). CD8 acts as a coreceptor with MHC class Irestricted T cell receptors in antigen recognition and T cell activation and has been shown to play a role in thymic differentiation. Two domains in CD8a are important for function: the extracellular IgSF domain binds the alpha3 domain of MHC class I and the cytoplasmic CXCP motif binds the tyrosine kinase p56 Lck. - Antikörper
Tag:
Mouse IgG1
Buffer:
PBS, 0.2% BSA, 0.03% Proclin 300, pH7.4
Form:
Liquid
Target:
CD8
Application Notes:
This APC-CY7-CD8 Antibody is specifically developed for flow cytometry applications to detect the expression of CD8 on human cells. Additionally, the Human TBNK 6-color Cocktail Flow Panel kit (Cat. No. ICA-A001) is available, with the APC-CY7-CD8 Antibody being one component of the kit.
FABm003-05-200tests
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