CD34 molecule is a cluster of differentiation molecule present on certain cells within the human body. It is a cell surface glycoprotein and functions as a cellcell adhesion factor. It may also mediate the attachment of stem cells to bone marrow extracellular matrix or directly to stromal cells. As a ~ 110 kDa monomeric cell surface antigen, CD34 is highly glycosylated with nine potential Nlinked and numerous potential Olinked glycosylation sites in its extracellular domain. The CD34 protein is a member of a family of singlepass transmembrane sialomucin proteins that show expression on early hematopoietic and vascularassociated tissue. CD34 is also an important adhesion molecule and is required for T cells to enter lymph nodes. It is expressed on lymph node endothelia whereas the Lselectin to which it binds is on the T cell. It was indicated that CD34 is a phosphorylation target for activated PKC, and couples to the hematopoietic adapter protein CrkL, which were involved in CD34 signaling pathways. CD34 is abberantly expressed in many kinds of tumors and is implicated in leukemogenesis. - Antikörper
Tag:
Mouse IgG1 | Mouse kappa
Buffer:
PBS, pH7.4, 0.03% Proclin300, 0.2% BSA
Form:
Liquid
Target:
CD34
Application Notes:
Flow Cytometry (Evaluation of the expression of CD34 on Human cells).
FABm034-01-50tests
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