CD279, or programmed cell death protein 1 (PD1), is a 55 kD member of the immunoglobulin superfamily with an immunoreceptor tyrosinebased inhibitory motif (ITIM) in its cytoplasmic region. It is mainly expressed on activated T cells, B cells and myeloid cells, and negatively regulates immune responses by binding to its ligands PDL1 (B7H1) and PDL2 (B7DC), thereby inhibiting T cell proliferation and cytokine secretion. Dysregulatio of the PD1 pathway is linked to autoimmune diseases (e.g, rheumatoid arthritis, systemic lupus erythematosus) and tumor immune escape, makin it a key target for cancer immunotherapy. The antibody PE, antiHuman CD279 (PD1)AS630 binds specifically to CD279, facilitating relevant research. - Antikörper
Tag:
Mouse IgG2b | Mouse kappa
Buffer:
PBS, pH7.4, 0.03% Proclin300, 0.2% BSA
Form:
Liquid
Target:
CD279
Application Notes:
Flow Cytometry (Detection the expression of CD279 on Human cells).
FABm044-01-200tests
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