Cynomolgus / Rhesus macaque Fas Ligand / TNFSF6 Protein, His Tag, premium grade, Unconjugated, Human

Product Overview

• Article Name: Cynomolgus / Rhesus macaque Fas Ligand / TNFSF6 Protein, His Tag, premium grade, Unconjugated, Human
• Biozol Catalog Number: ABS-FAL-H5246-1MG
• Supplier Catalog Number: FAL-H5246-1mg
• Alternative Catalog Number: ABS-FAL-H5246-1MG
• Manufacturer: AcroBiosystems
• Host: Human
• Category: Proteine/Peptide
• Species Reactivity: Monkey
• Conjugation: Unconjugated

Product Description

Fas ligand is also known as FasL, CD178, CD95L, or TNFSF6, is a homotrimeric typeII transmembrane protein that belongs to the tumor necrosis factor (TNF) family. Its binding with its receptor induces apoptosis. Fas ligand/receptor interactions play an important role in the regulation of the immune system and the progression of cancer. Mature human Fas Ligand consists of a 179 amino acid (aa) extracellular domain (ECD), a 22 aa transmembrane segment, and a 80 aa cytoplasmic domain. Within the ECD, human Fas Ligand shares 81% and 78% aa sequence identity with mouse and rat Fas Ligand, respectively. Apoptosis triggered by FasFas ligand binding plays a fundamental role in the regulation of the immune system. Its functions include:Tcell homeostasis, cytotoxic Tcell activity, immune privilege, maternal tolerance, tumor counterattack. Defective Fasmediated apoptosis may lead to oncogenesis as well as drug resistance in existing tumors. Germline mutation of Fas is associated with autoimmune lymphoproliferative syndrome (ALPS), a childhood disorder of apoptosis. - Proteine/Peptide

Product Properties

• Molecular Weight: 18.8 kDa
• Tag: N-10*His
• NCBI: 63308
• Buffer: PBS, pH7.4
• Purity: 90%
• Form: Powder
• Target: FAS Ligand

Images

Immobilized Human Fas Protein, Fc Tag (Cat. No. FAS-H5252) at 5 µg/mL (100 µL/well) can bind Cynomolgus / Rhesus macaque Fas Ligand Protein, His Tag, premium grade (Cat. No. FAL-H5246) with a linear range of 1-31 ng/mL (QC tested).

Immobilized Cynomolgus / Rhesus macaque Fas Ligand Protein, His Tag, premium grade (Cat. No. FAL-H5246) at 2 µg/mL (100 µL/well) can bind Human Fas Protein, Fc Tag (Cat. No. FAS-H5252) with a linear range of 0.1-1 ng/mL (Routinely tested).

Cynomolgus / Rhesus macaque Fas Ligand Protein, His Tag, premium grade on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.