Human FAP Protein, Fc Tag, active dimer (MALS verified), Unconjugated

Product Overview

• Article Name: Human FAP Protein, Fc Tag, active dimer (MALS verified), Unconjugated
• Biozol Catalog Number: ABS-FAP-H5263-20UG
• Supplier Catalog Number: FAP-H5263-20ug
• Alternative Catalog Number: ABS-FAP-H5263-20UG
• Manufacturer: AcroBiosystems
• Host: Human
• Category: Proteine/Peptide
• Species Reactivity: Human
• Conjugation: Unconjugated

Product Description

FAP (also known as seprase) is a Type II transmembrane serine protease. Both plasma membrane and soluble forms exhibit postproline cleaving endopeptidase activity, with a marked preference for Ala/SerGlyProSer/Asn/Ala consensus sequences. Degrade also gelatin, heatdenatured type I collagen. Also has dipeptidyl peptidase activity, with a preference for AlaPro, IlePro, GlyPro, ArgPro and ProPro. The plasma membrane form, in association with either DPP4, PLAUR or integrins, is involved in the pericellular proteolysis of the extracellular matrix (ECM), and hence promotes cell adhesion, migration and invasion through the ECM. Promotes glioma cell invasion through the brain parenchyma by degrading the proteoglycan brevican. Acts as a tumor suppressor in melanocytic cells through regulation of cell proliferation and survival in a serine protease activityindependent manner. - Proteine/Peptide

Product Properties

• Molecular Weight: 111.5 kDa
• Tag: N-Fc
• NCBI: 12884
• Buffer: PBS, pH7.4
• Purity: 95%
• Form: Powder
• Target: FAP

Images

Immobilized Human FAP, Fc Tag (Cat. No. FAP-H5263) at 1 µg/mL (100 µL/well) can bind Anti-FAP Antibody, Mouse IgG2a (FAP5) with a linear range of 0.2-3 ng/mL (QC tested).

Immobilized Anti-FAP Antibody, Mouse IgG2a (FAP5) at 1 µg/mL (100 µL/well) can bind Human FAP, Fc Tag (Cat. No. FAP-H5263) with a linear range of 0.5-4 ng/mL (Routinely tested).

Human FAP, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.