Human FKBP12 / FKBP1A Protein, His Tag, Unconjugated, E. coli

Product Overview

• Article Name: Human FKBP12 / FKBP1A Protein, His Tag, Unconjugated, E. coli
• Biozol Catalog Number: ABS-FKA-H5122-100UG
• Supplier Catalog Number: FKA-H5122-100ug
• Alternative Catalog Number: ABS-FKA-H5122-100UG
• Manufacturer: AcroBiosystems
• Host: E. coli
• Category: Proteine/Peptide
• Species Reactivity: Human
• Conjugation: Unconjugated

Product Description

Peptidylprolyl cistrans isomerase FKBP1A, a member of the FKBPtype PPIase family and FKBP1 subfamily, is also known as FK506binding protein 1A, immunophilin FKBP12 and 12 kDa FK506binding protein, which contains one PPIase FKBPtype domain. FKBP1A is a cistrans prolyl isomerase that binds the immunosuppressants FK506 (tacrolimus) and rapamycin (sirolimus).FKBP1A interacts with several intracellular signal transduction proteins including type I TGFbeta receptor. FKBP1A can also interact with multiple intracellular calcium release channels including the tetrameric skeletal muscle ryanodine receptor. Furthermore, FKBP1A can recruite SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. - Proteine/Peptide

Product Properties

• Molecular Weight: 12.8 kDa
• Tag: C-6*His
• NCBI: 62942
• Buffer: 50 mM HEPES, 150 mM NaCl, pH7.5
• Purity: 95%
• Form: Powder
• Target: FKBP12

Images

Human FKBP12, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.