FMSlike tyrosine kinase 3 ligand (Flt3 Ligand) is also known as FL, Flt3L and FLT3LG, is an alphahelical cytokine that promotes the differentiation of multiple hematopoietic cell lineages. FLT3LG is expressed as a noncovalentlylinked dimer by T cells and bone marrow and thymic fibroblasts. Each 36 kDa chain carries approximately 12 kDa of N and O linked carbohydrates. FLT3LG is structurally homologous to stem cell factor (SCF) and colony stimulating facor 1 (CSF1). FLT3LG acts as a growth factor that increases the number of immune cells by activating the hematopoietic progenitors. It also induces the mobilization of the hematopoietic progenitors and stem cells in vivo which may help the system to kill cancer cells. FLT3LG induces the expansion of monocytes and immature dendritic cells as well as early B cell lineage differentiation. FLT3LG cooperates with IL2, IL6, IL7, and IL15 to induce NK cell development and with IL3, IL7 and IL11 to induce terminal B cell maturation. Animal studies also show FLT3LG to reduce the severity of experimentally induced allergic inflammation. FLT3LG is crucial for steadystate pDC and cDC development. A lack of FLT3L results in low levels of DCs. - Proteine/Peptide
Immobilized Human Flt-3, Fc Tag (Cat. No. FL3-H5258) at 2 µg/mL (100 µL/well) can bind Human Flt-3 Ligand, His Tag (Cat. No. FLL-H5223) with a linear range of 0.1-3 ng/mL (QC tested).
Human Flt-3 Ligand, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.
* VAT and and shipping costs not included. Errors and price changes excepted
