Monoclonal Anti-FMC63 Antibody, Mouse IgG1 (Y45) (Carrier-free) (recommended for ADA assay), Unconjugated, Human
Biozol Catalog Number:
ABS-FM3-Y45A1-25UG
Supplier Catalog Number:
FM3-Y45A1-25ug
Alternative Catalog Number:
ABS-FM3-Y45A1-25UG
Manufacturer:
AcroBiosystems
Host:
Human
Category:
Antikörper
Species Reactivity:
Mouse
Conjugation:
Unconjugated
FMC63 is an IgG2a mouse monoclonal antibody specific for CD19, which is a target for the immunotherapy of B lineage leukaemias and lymphomas. FMC63 scFv is the most commonly used ectodomain component of CD19specific CARs. So far, most of reported CART19 trials contain the antiCD19 scFv derived from FMC63, including the two FDAapproved CARs Kymriah and Yescarta. - Antikörper
Tag:
Mouse IgG1 | Mouse Kappa
Buffer:
PBS, pH7.4
Purity:
0.95
Form:
Powder
Target:
FMC63
Immobilized FMC63 scFv, His Tag (Cat. No. CD9-M52Hb) at 2 µg/mL (100 µL/well) can bind Monoclonal Anti-FMC63 Antibody, Mouse IgG1 (Y45) (Cat. No. FM3-Y45A1) with a linear range of 0.1-6 ng/mL. FMC63 scFv, His Tag (Cat. No. CD9-M52Hb) is verified not recoginized by Mouse IgG1 Kappa Isotype Control (mAb) (Cat. No. DNP-M1) in low concentration (QC tested).
ELISA analysis shows that the binding of Human CD19, Fc Tag (Cat. No. CD9-H5251) to FMC63 scFv, His Tag (Cat. No. CD9-M52Hb) was inhibited by increasing concentration of Monoclonal Anti-FMC63 Antibody, Mouse IgG1 (Y45) (Cat. No. FM3-Y45A1). The concentration of Human CD19, Fc Tag used is 5 µg/mL (100 µL/well). The IC50 is 0.084 µg/mL (Routinely tested).
Monoclonal Anti-FMC63 Antibody, Mouse IgG1 (Y45) on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 0.95.
FM3-Y45A1-25ug
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