Human FOLR1 Protein, His Tag, low endotoxin (Folic Acid Complex), Unconjugated
Biozol Catalog Number:
ABS-FO1-H52H3-1MG
Supplier Catalog Number:
FO1-H52H3-1mg
Alternative Catalog Number:
ABS-FO1-H52H3-1MG
Manufacturer:
AcroBiosystems
Host:
Human
Category:
Proteine/Peptide
Species Reactivity:
Human
Conjugation:
Unconjugated
Folate Receptor 1 (FOLR1) is also known as Folate receptor alpha, Folate Binding Protein (FBP), FOLR, and is a member of the folate receptor (FOLR) family. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and mediate delivery of 5methyltetrahydrofolate to the interior of cells. Mature FOLR1 is an Nglycosylated protein that is anchored to the cell surface by a GPI linkage. FOLR1 is predominantly expressed on epithelial cells and is dramatically upregulated on many carcinomas. FOLR1 is internalized to the endosomal system where it dissociates from its ligand before recycling to the cell surface. A soluble form of FOLR1 can be proteolytically shed from the cell surface into the serum and breast milk. Defects in FOLR1 are the cause of neurodegeneration due to cerebral folate transport deficiency (NCFTD). NCFTD is an autosomal recessive disorder resulting from brainspecific folate deficiency early in life. - Proteine/Peptide
Immobilized Mirvetuximab at 1 µg/mL (100 µL/well) can bind Human FOLR1 Protein, His Tag (Cat. No. FO1-H52H3) with a linear range of 0.2-4 ng/mL (QC tested).
Immobilized Folic Acid-BSA Conjugate at 5 µg/mL (100 µL/well) can bind Human FOLR1 Protein, His Tag (Cat. No. FO1-H52H3) with a linear range of 0.078-1.25 µg/mL (QC tested).
Human FOLR1 Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.
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