Biotinylated Human FOLR1 Protein, His,Avitag(TM) (Folic Acid Free, MALS verified)
Biozol Catalog Number:
ABS-FO1-H82E2-25UG
Supplier Catalog Number:
FO1-H82E2-25ug
Alternative Catalog Number:
ABS-FO1-H82E2-25UG
Manufacturer:
AcroBiosystems
Host:
Human
Category:
Proteine/Peptide
Species Reactivity:
Human
Conjugation:
Biotin
Folate Receptor 1 (FOLR1) is also known as Folate receptor alpha, Folate Binding Protein (FBP), FOLR, and is a member of the folate receptor (FOLR) family. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and mediate delivery of 5methyltetrahydrofolate to the interior of cells. Mature FOLR1 is an Nglycosylated protein that is anchored to the cell surface by a GPI linkage. FOLR1 is predominantly expressed on epithelial cells and is dramatically upregulated on many carcinomas. FOLR1 is internalized to the endosomal system where it dissociates from its ligand before recycling to the cell surface. A soluble form of FOLR1 can be proteolytically shed from the cell surface into the serum and breast milk. Defects in FOLR1 are the cause of neurodegeneration due to cerebral folate transport deficiency (NCFTD). NCFTD is an autosomal recessive disorder resulting from brainspecific folate deficiency early in life. - Proteine/Peptide
Immobilized Folic acid-BSA conjugate at 5 µg/mL (100 µL/well) can bind Biotinylated Human FOLR1, His,Avitag (Cat. No. FO1-H82E2) with a linear range of 0.004-0.125 µg/mL (QC tested).
Immobilized Mouse Anti-FOLR1 Antibody at 1 µg/mL (100 µL/well) can bind Biotinylated Human FOLR1, His,Avitag (Cat. No. FO1-H82E2) with a linear range of 0.1-2 ng/mL (Routinely tested).
FO1-H82E2-25ug
Biotinylated Human FOLR1, His,Avitag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
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