Monoclonal Anti-Hendra virus F glycoprotein Antibody, Human IgG1 (3F4) (MALS verified), Unconjugated
Biozol Catalog Number:
ABS-FUN-MY2098-100UG
Supplier Catalog Number:
FUN-MY2098-100ug
Alternative Catalog Number:
ABS-FUN-MY2098-100UG
Manufacturer:
AcroBiosystems
Host:
Human
Category:
Antikörper
Species Reactivity:
Mouse
Conjugation:
Unconjugated
Hendra virus (HeV) and Nipah virus (NiV) are henipaviruses discovered in the midto late 1990s that possess a broad host tropism and are known to cause severe and often fatal disease in both humans and animals. HeV and NiV infect host cells through the coordinated efforts of two envelope glycoproteins. The G glycoprotein attaches to cell receptors, triggering the fusion (F) glycoprotein to execute membrane fusion. G is a type II homotetrameric transmembrane protein responsible for binding to ephrinB2 or ephrinB3 (ephrinB2/B3) receptors. F is a homotrimeric type I transmembrane protein that is synthesized as a premature F0 precursor and cleaved by cathepsin L during endocytic recycling to yield the mature, disulfidelinked, F1 and F2 subunits. Upon binding to ephrinB2/B3, NiV G undergoes conformational changes leading to F triggering and insertion of the F hydrophobic fusion peptide into the target membrane. Subsequent refolding into the more stable postfusion F conformation drives merger of the viral and host membranes to form a pore for genome delivery to the cell cytoplasm. - Antikörper
Tag:
Human IgG1 | Human Kappa
Buffer:
PBS, pH7.4
Purity:
0.95
Form:
Powder
Target:
Fusion glycoprotein
FUN-MY2098-100ug
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