Cynomolgus LRRC32&TGF-beta 1 Heterotrimer Protein, His Tag&Tag Free, Unconjugated, Human
Biozol Catalog Number:
ABS-GA1-C52W7-100UG
Supplier Catalog Number:
GA1-C52W7-100ug
Alternative Catalog Number:
ABS-GA1-C52W7-100UG
Manufacturer:
AcroBiosystems
Host:
Human
Category:
Proteine/Peptide
Species Reactivity:
Monkey
Conjugation:
Unconjugated
GARP (LRRC32) is a transmembrane protein that binds latentTGFbeta1 and tethers it on the Treg surface. and has been proved to promote the activation and secretion of transforming growth factor beta (TGFbeta). The expression of GARP is highly on the surface activated Tregs and increases the suppressive function of Tregs. Additionally, GARP can bind to latent transforming growth factor beta (TGFbeta), thus promoting secretion and activation of TGFbeta. TGFbeta plays a critical rule for homeostasis and function of Tregs. Notably, it has been also observed that fibroblasts and endothelial cell lines that express GARP/latent TGFbeta1 complexes do not activate TGFbeta1. However, it cannot be excluded that specific stimuli are required to trigger TGFbeta1 activation from complexes on the surface of these cell types. - Proteine/Peptide
Immobilized Cynomolgus LRRC32&TGF-beta 1 Heterotrimer Protein, His Tag&Tag Free (Cat. No. GA1-C52W7) at 1 µg/mL (100 µL/well) can bind Biotinylated Human ITGAV&ITGB6 Heterodimer Protein, His,Avitag&Tag Free (Cat. No. IT6-H82E4) with a linear range of 1-39 ng/mL (QC tested).
Cynomolgus LRRC32&TGF-beta 1 Heterotrimer Protein, His Tag&Tag Free on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.
GA1-C52W7-100ug
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