Human G-CSF R / CD114 Protein, His Tag, Unconjugated

Product Overview

• Article Name: Human G-CSF R / CD114 Protein, His Tag, Unconjugated
• Biozol Catalog Number: ABS-GCR-H5223-100UG
• Supplier Catalog Number: GCR-H5223-100ug
• Alternative Catalog Number: ABS-GCR-H5223-100UG
• Manufacturer: AcroBiosystems
• Host: Human
• Category: Proteine/Peptide
• Species Reactivity: Human
• Conjugation: Unconjugated

Product Description

Granulocyte Colony Stimulating Factor Receptor (GCSFR) is also known as Cluster of Differentiation 114 (CD114), CSF3R and GCSF, is a cellsurface receptor for the granulocyte colonystimulating factor (GCSF), a cytokine that plays a critical role in the regulation of the activation, proliferation, differentiation, and survival of the neutrophilic granulocyte lineage. GCSFR belongs to a family of cytokine receptors known as the hematopoietin receptor family. This type I membrane protein has a composite structure consisting of an immunoglobulin(Ig)like domain, a cytokine receptorhomologous (CRH) domain and three fibronectin type I II (FNIII) domains in the extracellular region. GCSFR is present mainly on precursor cells in the bone marrow, and, in response to stimulation by GCSF, initiates cell proliferation and differentiation into mature neutrophilic granulocytes and macrophages. GCSFR mediates the specific effect of GCSF through activating a variety of intracellular signaling cascades, including the Jak/Stat, PI3/Akt, RasRafMAP kinase, and Src family kinase pathways, and thus functions in defense against infection, inflammation and repair, and in the maintenance of steady state hematopoiesis. Mutations in this gene are a cause of Kostmann syndrome, also known as severe congenital neutropenia. Mutations in the intracellular part of this receptor are also associated with certain types of leukemia. - Proteine/Peptide

Product Properties

• Molecular Weight: 67.4 kDa
• Tag: C-6*His
• NCBI: 000751
• Buffer: PBS, pH7.4
• Purity: 95%
• Form: Powder
• Target: G-CSF R

Images

Immobilized ActiveMax Human G-CSF, Tag Free (Cat. No. GCF-H5214) at 2 µg/mL (100 µL/well) can bind Human G-CSF R, His Tag (Cat. No. GCR-H5223) with a linear range of 0.01-0.313 µg/mL (QC tested).

Human G-CSF R, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.