Cynomolgus GDF-15 / MIC-1 Protein, His Tag, Unconjugated, E. coli

Product Overview

• Article Name: Cynomolgus GDF-15 / MIC-1 Protein, His Tag, Unconjugated, E. coli
• Biozol Catalog Number: ABS-GD5-C5148-100UG
• Supplier Catalog Number: GD5-C5148-100ug
• Alternative Catalog Number: ABS-GD5-C5148-100UG
• Manufacturer: AcroBiosystems
• Host: E. coli
• Category: Proteine/Peptide
• Species Reactivity: Monkey
• Conjugation: Unconjugated

Product Description

Growth Differentiation Factor 15 (GDF15), also called Macrophage Inhibitory Cytokine 1 (MIC1). Expression of MIC1 mRNA in monocytoid cells is upregulated by a variety of stimuli associated with activation, including interleukin 1beta, tumor necrosis factor alpha (TNFalpha), interleukin 2, and macrophage colonystimulating factor but not interferon gamma, or lipopolysaccharide (LPS). It is highly expressed in cardiomyocytes, adipocytes, macrophages, endothelial cells, and vascular smooth muscle cells in normal and pathological condition. GDF15 increases during tissue injury and inflammatory states and is associated with cardiometabolic risk. Increased GDF15 levels are associated with cardiovascular diseases such as hypertrophy, heart failure, atherosclerosis, endothelial dysfunction, obesity, insulin resistance, diabetes, and chronic kidney diseases in diabetes. Increased GDF15 level is linked with the progression and prognosis of the disease condition. - Proteine/Peptide

Product Properties

• Molecular Weight: 14.4 kDa
• Tag: N-10*His
• NCBI: 7
• Buffer: 20 mM Citric acid, pH2.2
• Purity: 95%
• Form: Powder
• Target: GDF-15

Images

Immobilized Cynomolgus GDF-15, His Tag (Cat. No. GD5-C5148) at 1 µg/mL (100 µL/well) can bind Human GFR alpha-like, Fc Tag (Cat. No. GFE-H5259) with a linear range of 0.8-25 ng/mL (QC tested).

Cynomolgus GDF-15, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.