Human GFR alpha-like Protein, Fc Tag, Unconjugated
Biozol Catalog Number:
ABS-GFE-H5259-100UG
Supplier Catalog Number:
GFE-H5259-100ug
Alternative Catalog Number:
ABS-GFE-H5259-100UG
Manufacturer:
AcroBiosystems
Host:
Human
Category:
Proteine/Peptide
Species Reactivity:
Human
Conjugation:
Unconjugated
GFR alphalike is also known as GDNF family receptor alphalike, GFRAL, C6orf144, UNQ9356, PRO34128. Growth differentiation factor15 (GDF15) is a circulating protein that has been implicated in multiple biological processes, including energy homeostasis, body weight regulation, and cachexia driven by cancer and chronic disease. GDNF family receptor alphalike (GFRAL) was recently identified as the neuronal brainstem receptor responsible for mediating the anorectic actions of GDF15. Brainstemrestricted receptor for GDF15 which regulates food intake, energy expenditure and body weight in response to metabolic and toxininduced stresses . Upon interaction with its ligand, GDF15, interacts with RET and induces cellular signaling through activation of MAPK and AKT signaling pathways. - Proteine/Peptide
50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5
Purity:
95%
Form:
Powder
Target:
GFR alpha-like
Immobilized Human GDF-15, His Tag (Cat. No. GD5-H5149) at 1 µg/mL (100 µL/well) can bind Human GFR alpha-like, Fc Tag (Cat. No. GFE-H5259) with a linear range of 0.4-25 ng/mL (QC tested).
Human GFR alpha-like, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
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