Human Glucosylceramidase Protein, His Tag, Unconjugated 1 mg

Product Overview

• Article Name: Human Glucosylceramidase Protein, His Tag, Unconjugated 1 mg
• Biozol Catalog Number: ABS-GLE-H52H3-1MG
• Supplier Catalog Number: GLE-H52H3-1mg
• Alternative Catalog Number: ABS-GLE-H52H3-1MG
• Manufacturer: AcroBiosystems
• Host: Human
• Category: Proteine/Peptide
• Species Reactivity: Human
• Conjugation: Unconjugated

Product Description

Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose. Thereby, it plays a central role in the degradation of complex lipids and the turnover of cellular membranes. Through the production of ceramides,it participates in the PKCactivated salvage pathway of ceramide formation and plays a role in cholesterol metabolism. It may either catalyze the glucosylation of cholesterol, through a transglucosylation reaction that transfers glucose from glucosylceramide to cholesterol. Defects in Glucosylceramidase are the cause of Gaucher disease, also known as glucocerebrosidase deficiency. Gaucher disease is the most prevalent lysosomal storage disease, characterized by accumulation of glucosylceramide in the reticuloendothelial system. Currently, enzyme replacement therapy is used to treat patients with the disease. - Proteine/Peptide

Product Properties

• Molecular Weight: 57.5 kDa
• Tag: C-10*His
• NCBI: 04062
• Buffer: 0.1 M Sodium citrate, pH5.5
• Purity: 90%
• Form: Liquid
• Target: Glucosylceramidase

Images

Human Glucosylceramidase, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.