Human cytomegalovirus (HCMV), a prototypical betaherpes virus, is a major cause of morbidity and mortality in immunocompromised transplant recipients and congenitally infected fetuses.Different HCMV glycoprotein complexes are capable of meditating entry through interaction with cellspecific receptors on a panel of host cells. The pentamer (gH/gL/UL128/UL130/UL131A) mediates HCMV entry into epithelial, endothelial, and myeloid cells by its binding to neuropilin 2 (Nrp2). The trimer (gH/gL/gO) can mediate infection of all cell types by binding to plateletderived growth factoralpha (PDGFRalpha). Both pentamer and trimer need to interact with the glycoprotein B (gB), the fusogenic protein, to trigger the virus and host cell membrane fusion. - Antikörper
Tag:
Human IgG1 | Human Kappa
Buffer:
PBS, pH7.4
Purity:
0.95
Form:
Powder
Target:
Glycoprotein H & Glycoprotein L & Glycoprotein O/gH & gL & gO (HCMV)
Immobilized Human Cytomegalovirus (strain AD169) (HHV-5) Glycoprotein H&L&O, His Tag (Cat. No. GLO-V5243) at 1 µg/mL (100 µL/well) can bind Monoclonal Anti-Human Cytomegalovirus (strain AD169) Glycoprotein H&L&O Antibody, Human IgG1 (2B1) (Cat. No. GLO-MY2285) with a linear range of 0.06-4 ng/mL (QC tested).
Immobilized HHV-5 (strain AD169) Glycoprotein H&L, His Tag (Cat. No. GHL-H5243) at 1 µg/mL (100 µL/well) can bind Monoclonal Anti-Human Cytomegalovirus (strain AD169) Glycoprotein H&L&O Antibody, Human IgG1 (2B1) (Cat. No. GLO-MY2285) with a linear range of 0.06-1 ng/mL (Routinely tested).
Monoclonal Anti-Human Cytomegalovirus (strain AD169) Glycoprotein H&L&O Antibody, Human IgG1 (2B1) on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 0.95.
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