GMP Human GDNF Protein (E. coli), Unconjugated

Product Overview

• Article Name: GMP Human GDNF Protein (E. coli), Unconjugated
• Biozol Catalog Number: ABS-GMP-GDFH17-50UG
• Supplier Catalog Number: GMP-GDFH17-50ug
• Alternative Catalog Number: ABS-GMP-GDFH17-50UG
• Manufacturer: AcroBiosystems
• Host: E. coli
• Category: Proteine/Peptide
• Species Reactivity: Human
• Conjugation: Unconjugated

Product Description

Glial cell linederived neurotrophic factor (GDNF) is a neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their highaffinity dopamine uptake. GDNF is a glycosylated, disulfidebonded homodimer that is a distantly related member of the transforming growth factorbeta superfamily. The GDNF family members (consists of GDNF, neurturin, artemin and persephin) are structurally similar to transforming growth factorbeta. Unlike other members of the TGFbeta superfamily, which signal through the receptor serinethreonine kinases, GDNF family ligands activate intracellular signalling cascades via the receptor tyrosine kinase Ret. GDNF family ligands binds to GDNF family receptor alpha (GFRalpha) and then the GDNF family ligandGFR alpha complex binds to and stimulates autophosphorylation of Ret. - Proteine/Peptide

Product Properties

• Molecular Weight: 15.2 kDa
• Tag: Native
• NCBI: 39905
• Buffer: 20 mM Sodium Citrate, 150 mM NaCl, pH4.0
• Purity: 95%
• Form: Powder-GMP
• Target: GDNF

Images

GMP Human GDNF Protein(E. coli) on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.