The colony stimulating factor 1 (CSF1), also known as macrophage colonystimulating factor (MCSF), is a secreted cytokine which influences hematopoietic stem cells to differentiate into macrophages or other related cell types. Eukaryotic cells also produce MCSF in order to combat intercellular viral infection. It is one of the three experimentally described colonystimulating factors. MCSF binds to the colony stimulating factor 1 receptor. Macrophage colonystimulating factor has been shown to interact with PIK3R2. MCSF (or CSF1) is a hematopoietic growth factor that is involved in the proliferation, differentiation, and survival of monocytes, macrophages, and bone marrow progenitor cells. Locally produced MCSF in the vessel wall contributes to the development and progression of atherosclerosis. - Proteine/Peptide
