HIV-1 (HXB2) GP41 Pre-hairpin intermediate Protein, His Tag, Unconjugated, E. coli
Biozol Catalog Number:
ABS-GP1-H51H3-50UG
Supplier Catalog Number:
GP1-H51H3-50ug
Alternative Catalog Number:
ABS-GP1-H51H3-50UG
Manufacturer:
AcroBiosystems
Host:
E. coli
Category:
Proteine/Peptide
Species Reactivity:
Virus
Conjugation:
Unconjugated
Infection by HIV1 involves the fusion of viral and cellular membranes with subsequent transfer of viral genetic material into the cell. The HIV1 envelope glycoprotein that mediates fusion consists of the surface subunit gp120 and the transmembrane subunit gp41. gp120 directs virion attachment to the cellsurface receptors, and gp41 then promotes viralcell membrane fusion. A soluble, alphahelical, trimeric complex within gp41 composed of Nterminal and Cterminal extraviral segments has been proposed to represent the core of th e fusionactive conformation of the HIV1 envelope. Three Nterminal helices within the bundle form a central, parallel, trimeric coiled coil, whereas three Cterminal helices pack in the reverse direction into three hydrophobic grooves on the surface of the Nterminal trimer. This thermostable subdomain displays the salient features of the core structure of the isolated gp41 subunit and thus provides a possible target for therapeutics designed selectively to block HIV1 entry. - Proteine/Peptide
Immobilized HIV-1 (HXB2) GP41 Pre-hairpin intermediate Protein, His Tag (Cat. No. GP1-H51H3) at 1 µg/mL (100 µL/well) can bind Monoclonal Anti-HIV-1 GP41 Antibody, Human IgG1 (2F5) with a linear range of 0.2-16 ng/mL (QC tested).
HIV-1 (HXB2) GP41 Pre-hairpin intermediate Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 85%.
GP1-H51H3-50ug
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