Human Glypican 2 / GPC2 Protein, His Tag, Unconjugated

Product Overview

• Article Name: Human Glypican 2 / GPC2 Protein, His Tag, Unconjugated
• Biozol Catalog Number: ABS-GP2-H52H3-100UG
• Supplier Catalog Number: GP2-H52H3-100ug
• Alternative Catalog Number: ABS-GP2-H52H3-100UG
• Manufacturer: AcroBiosystems
• Host: Human
• Category: Proteine/Peptide
• Species Reactivity: Human
• Conjugation: Unconjugated

Product Description

Glypican 2 (GPC2), also known cerebroglycan, is a glycophosphatidylinositollinked integral membrane heparan sulfate proteoglycan found in the developing nervous system. Cerebroglycan participates in cell adhesion and is thought to regulate the growth and guidance of axons. Cerebroglycan has especially high affinity for laminin1. GPC2 silencing inactivates Wnt/betacatenin signaling and reduces the expression of NMyc, an oncogenic driver of neuroblastoma tumorigenesis. Immunotoxins and chimeric antigen receptor (CAR) T cells targeting GPC2 inhibit neuroblastoma growth in mouse models. A GPC3 specific antibody drug conjugate (ADC) can also inhibit neuroblastoma cell proliferation. - Proteine/Peptide

Product Properties

• Molecular Weight: 60.0 kDa
• Tag: C-10*His
• NCBI: 8
• Buffer: PBS, pH7.4
• Purity: 90%
• Form: Powder
• Target: Glypican 2

Images

Immobilized Recombinant Human Midkine Protein at 2 µg/mL (100 µL/well) can bind Human Glypican 2, His Tag (Cat. No. GP2-H52H3) with a linear range of 2-32 ng/mL (QC tested).

Human Glypican 2, His Tag on SDS-PAGE under non-reducing (NR) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.

GP2-H52H3-100ug