Human Granzyme B Protein, Tag Free (active enzyme), Unconjugated 20 ug

Product Overview

• Article Name: Human Granzyme B Protein, Tag Free (active enzyme), Unconjugated 20 ug
• Biozol Catalog Number: ABS-GZB-H5213-20UG
• Supplier Catalog Number: GZB-H5213-20ug
• Alternative Catalog Number: ABS-GZB-H5213-20UG
• Manufacturer: AcroBiosystems
• Host: Human
• Category: Proteine/Peptide
• Species Reactivity: Human
• Conjugation: Unconjugated

Product Description

Granzyme B (GZMB) is a cytosolic protease abundant in cytotoxic Tcells and natural killer cells, pivotal for immune defense. Delivered into target cells, GZMB activates caspaseindependent pyroptosis by cleaving gasderminE (GSDME). This triggers pyroptosis, leading to target cell death. GZMB exhibits substrate specificity for aspartate residue cleavage and contributes to an activation cascade of caspases, impacting apoptosis execution. Involved in bacterial infection response, GZMB cleaves and activates caspase7, promoting plasma membrane repair. Its multifaceted activities underscore its crucial role in immune responses and cellular defense. - Proteine/Peptide

Product Properties

• Molecular Weight: 25.5 kDa
• Tag: Native
• NCBI: 10144
• Buffer: 50 mM Tris, 150 mM NaCl, pH7.5
• Purity: 90%
• Form: Liquid
• Target: Granzyme B

Images

Human Granzyme B Protein, Tag Free on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.